Phenotype Image Detail

Image

Caption

Wwox^tm1.1Mald/Wwox^tm1.1Mald mice have abnormal spleens and thymuses. Histopathology of spleens (top four panels) and thymuses (bottom four panels) from 18 day old Wwox^tm1.1Mald/Wwox^tm1.1Mald (KO) and wild-type (WT) mice. Histological sections were stained with H&E. Note the significant atrophy of the spleen and the reduced cortical thickness in the thymus from the KO mice. Low power images of spleens (first row) and thymuses (third row) have a total magnification of 21X. High power images of spleens in (second row) have a total magnification of 84X and thymuses (bottom row) have a total magnification of 44X.

Copyright

This image is from Ludes-Meyers JH, PLoS One 2009;4(11):e7775, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:155406

Associated Alleles

Symbol	Name
Wwox^tm1.1Mald	WW domain-containing oxidoreductase; targeted mutation 1.1, Marcelo Aldaz

Associated Genotypes

Allelic Composition	Genetic Background
Wwox^tm1.1Mald/Wwox^tm1.1Mald	involves: C57BL/6 * FVB/N