Phenotype Image Detail

Image

Caption

Histomorphometric analysis. (A) MicroCT images of femurs from postnatal day 18 mice. Note the dramatic difference in bone structure of the femur from Wwox^tm1.1Mald/Wwox^tm1.1Mald (KO) mice vs wild-type (WT) and heterozygous (HET) mice bones (B) Von Kossa stained sections of femurs from mice of the indicated genotypes. Black stained areas represent mineralized bone tissue. Note the significantly decreased mineralization in the KO mice bone sample (C) Quantitative histomorphometric analyses of postnatal day 18 day mice. We did not observe differences between WT and HET mice, therefore, we compared KO data (n = 3) with WT and HET data combined (WT+HET, n = 5). Wild-type-WT, heterozygote- HET, knockout-KO. BV/TV%-bone volume/tissue volume, Md.V/TV%- mineralized volume/tissue volume, Tb.N-Trabecular number (1/mm), Tb.Th-Trabecular thickness (micrometers). *p<0.05.

Copyright

This image is from Ludes-Meyers JH, PLoS One 2009;4(11):e7775, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:155406

Associated Alleles

Symbol	Name
Wwox^tm1.1Mald	WW domain-containing oxidoreductase; targeted mutation 1.1, Marcelo Aldaz

Associated Genotypes

Allelic Composition	Genetic Background
Wwox^tm1.1Mald/Wwox^tm1.1Mald	involves: C57BL/6 * FVB/N