Phenotype Image Detail

Image

Caption

Enhanced osteoclast differentiation in Id1^tm1Zhu/Id1^tm1Zhu mice. Enzyme histochemistry staining for TRAP on femoral sections (200X) of wild-type (WT) and Id1^tm1Zhu/Id1^tm1Zhu (Id1-/-) mice. Arrowheads indicate TRAP+ osteoclasts stained in red. (D) Bone marrow (BM) cells were cultured in the presence of M-CSF and RANKL for 3 days and then subjected to TRAP staining (400X). (E) BM cells were plated on a BD BioCoat Osteologic slide and cultured in the presence of M-CSF and RANKL for 10 days. The area resorbed was visualized by von Kossa staining (40X). (A-E) *P<0.05, **P<0.01; n = 5. Error bars represent +/-S.E.M.

Copyright

This image is from Chan AS, PLoS One 2009;4(11):e7955, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:155384

Associated Alleles

Symbol	Name
Id1^tm1Zhu	inhibitor of DNA binding 1, HLH protein; targeted mutation 1, Yuan Zhuang

Associated Genotypes

Allelic Composition	Genetic Background
Id1^tm1Zhu/Id1^tm1Zhu	involves: 129S1/Sv * C57BL/6