Phenotype Image Detail

Image

Caption

Amyloid pathology and glial inflammation in Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte mouse brain. B, Congo-red stained plaque core (red) in the frontal cortex of a Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0 (hemizygous) ARTE10 mouse at 5 months of age. The green bi-refringence in polarized light (inset) is diagnostic of amyloid. C, D, Thioflavin-S positive plaque cores (green), each encircled by a sphere (corona) of dilated, strongly ubiquitin-positive dystrophic neurites (red) in the subiculum of a Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte (homozygous) ARTE10 mouse at 3 months of age (D) and in the frontal cortex of a 19 months old hemizygous mouse (C), the latter with concomitant amyloid angiopathy (arrow). E, F, AT8-positive hyperphosphorylated tau (red) in dystrophic neurites adjacent to plaque cores (green: Ab40 and Ab42) in homozygous ARTE10 mice at 12 (E) and 8 (F) months of age.

Copyright

This image is from Willuweit A, PLoS One 2009;4(11):e7931, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:155410

Associated Alleles

Symbol	Name
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte	transgene insertion 10, TaconicArtemis

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte	involves: C57BL/6 * CBA
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0	involves: C57BL/6 * CBA