Phenotype Image Detail

Image

Caption

Hematoxylin and Eosin staining of sections of renal cortex from wild-type (WT), Ptgs2^tm1Unc/Ptgs2^tm1Unc (COX-2 null) and Ptgs2^tm1.1Wls/Ptgs2^tm1.1Wls (Delta18 COX-2) mice. Kidneys were harvested from mice after euthanasia and fixed in 10% formalin in phosphate-buffered saline, pH 7.4. Kidneys were embedded in paraffin for staining with H & E. A. Renal cortex from WT mouse. B. Renal cortex from Ptgs2^tm1Unc/Ptgs2^tm1Unc mouse. C. Renal cortex from Ptgs2^tm1.1Wls/Ptgs2^tm1.1Wls mouse. (Original magnification, x 200) Arrows indicate glomeruli. The results show that the renal cortex in Ptgs2^tm1Unc/Ptgs2^tm1Unc mice exhibit glomerular hypoplasia and hypertrophy of glomeruli as reported previously, but sections from renal cortex of WT and Ptgs2^tm1.1Wls/Ptgs2^tm1.1Wls mice are morphologically indistinguishable.

Copyright

This image is from Wada M, J Biol Chem 2009 Nov 6;284(45):30742-53 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:156331

Associated Alleles

Symbol	Name
Ptgs2^tm1.1Wls	prostaglandin-endoperoxide synthase 2; targeted mutation 1.1, William L Smith
Ptgs2^tm1Unc	prostaglandin-endoperoxide synthase 2; targeted mutation 1, University of North Carolina

Associated Genotypes

Allelic Composition	Genetic Background
Ptgs2^tm1Unc/Ptgs2^tm1Unc	B6;129P2-Ptgs2^tm1Unc/Tac
Ptgs2^tm1.1Wls/Ptgs2^tm1.1Wls	B6.129-Ptgs2^tm1.1Wls