Phenotype Image Detail

Image

Caption

Photograph of a 10-day-old Paxx^em1Spj/Paxx^em1Spj Nhej1^tm1Fwa/Nhej1^tm1Fwa (Paxx-/- Xlf-/-) mouse as compared with a littermate control, Nhej1^tm1Fwa/Nhej1^tm1Fwa (Xlf-/-) mouse. Isolated spleens and thymus of the represented mice are shown. In the case of the double mutant mouse no thymus was identified.

Copyright

This image is from Balmus G, Genes Dev 2016 Oct 1;30(19):2152-2157, and is displayed with the permission of Cold Spring Harbor Laboratory Press, who owns the Copyright. J:236776

Associated Alleles

Symbol	Name
Nhej1^tm1Fwa	non-homologous end joining factor 1; targeted mutation 1, Frederick W Alt
Paxx^em1Spj	non-homologous end joining factor; endonuclease-mediated mutation 1, Stephen P Jackson

Associated Genotypes

Allelic Composition	Genetic Background
Paxx^em1Spj/Paxx^em1Spj Nhej1^tm1Fwa/Nhej1^tm1Fwa	involves: 129S6/SvEvTac * C57BL/6NTac