Phenotype Image Detail

Image

Caption

Defective placental development in the absence of EpCAM. (A) EpCAM expression in wild-type placentas at E9.5 as shown by immunofluorescence staining (left). Bar = 200 um. Right panel shows a schematic of E9.5 placenta. La = labyrinth, Sp= spongiotrophoblasts, TGC = parietal trophoblast giant cells, V = vasculature. (B) Morphology in H&E stained sections of heterozygous Epcam^{Gt(RST556)Byg} and Epcam^{Gt(RST556)Byg}/Epcam^{Gt(RST556)Byg} placentas. Bars = 50 and 20 um. Panels on the right represent high power view of insets in the left panels. Arrow in B highlights intravascular microthrombus.

Copyright

This image is from Nagao K, PLoS One 2009;4(12):e8543, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:155941

Associated Alleles

Symbol	Name
Epcam^Gt(RST556)Byg	epithelial cell adhesion molecule; gene trap RST556, BayGenomics

Associated Genotypes

Allelic Composition	Genetic Background
Epcam^Gt(RST556)Byg/Epcam^Gt(RST556)Byg	involves: 129P2/OlaHsd * C57BL/6