Phenotype Image Detail

Image

Caption

Tardbp^tm1.1Ckjs/Tardbp^tm1.1Ckjs embryos show defective development of the inner cell mass in vitro. Microscopic images of the wild-type (Tardbp+/+) (a), the heterozygous Tardbp^tm1.1Ckjs (Tardbp+/-) mutant (b) and the Tardbp^tm1.1Ckjs/Tardbp^tm1.1Ckjs (Tardbp-/-) mutant (c). Tardbp blastocysts were grown for 3 days in culture (6.5 days post-coitum). The trophoblast giant cells (T, the arrowheads) and the inner cell mass (ICM, the arrows) cells are indicated. Note the absence of the ICM in the homozygous mutant sample.

Copyright

This image is from Wu LS, Genesis 2010 Jan;48(1):56-62, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:155958

Associated Alleles

Symbol	Name
Tardbp^tm1.1Ckjs	TAR DNA binding protein; targeted mutation 1.1, C K James Shen

Associated Genotypes

Allelic Composition	Genetic Background
Tardbp^tm1.1Ckjs/Tardbp^tm1.1Ckjs	involves: C57BL/6J * FVB/N