Phenotype Image Detail

Image

Caption

In four week old mice, hematoxylin and eosin staining of control and Sox2^tm1.1Lan/Sox2^tm1.1Lan Tg(Scgb1a1-cre)1Kkw/0 (Sox2^delta/delta) lung sections demonstrated abnormal low cuboidal-to-squamous epithelium in large bronchioles (A, B) and small bronchioles (C,D). Immunohistochemical staining demonstrated loss of CCSP (Scgb1a1) a Clara cell marker (E,F), ciliated cell markers alpha-tubulin and FoxJ1 (G-J). Lung epithelial markers Nkx2.1 and FoxA2 were unchanged in control vs mutant mice (K-N). Arrows indicate regions shown in insets. Scale bar is 50 um, inset scale bar is 10 um.

Copyright

This image is from Tompkins DH, PLoS One 2009;4(12):e8248, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:155963

Associated Alleles

Symbol	Name
Sox2^tm1.1Lan	SRY (sex determining region Y)-box 2; targeted mutation 1.1, Richard A Lang

Associated Genotypes

Allelic Composition	Genetic Background
Sox2^tm1.1Lan/Sox2^tm1.1Lan Tg(Scgb1a1-cre)1Kkw/0	involves: 129/Sv * C57BL/6