Phenotype Image Detail

Image

Caption

Defect of large lysosome formation revealed by LAMP-1 staining in Enpp2^tm1Mmas/Enpp2^tm1Mmas (Enpp2-/-) visceral endoderm (VE) cells. Confocal microscopic images of VE cells stained with anti-LAMP-1 antibody (red) and Alexa488-phalloidin (green) are shown. LAMP-1-positive lysosomes were smaller in mutant VE cells than in wild-type (WT) VE cells. Scale bar represents 6 um.

Copyright

This image is from Koike S, J Biol Chem 2009 Nov 27;284(48):33561-70 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:156013

Associated Alleles

Symbol	Name
Enpp2^tm1Mmas	ectonucleotide pyrophosphatase/phosphodiesterase 2; targeted mutation 1, Masayuki Masu

Associated Genotypes

Allelic Composition	Genetic Background
Enpp2^tm1Mmas/Enpp2^tm1Mmas	involves: 129P2/OlaHsd * C57BL/6N