Phenotype Image Detail

Image

Caption

Abnormal differentiation of absorptive enterocytes in Tg(Vil1-cre)997Gum/0 Gadd45gip1^tm2Kong/Gadd45gip1^tm2Kong (Vil-Cre;Crif1^f/f) embryos. A-D, immunohistochemical analysis of the small intestine from E18.5 Gadd45gip1^tm2Kong/Gadd45gip1⁺ Tg(Vil1-cre)997Gum/0 (A and C) or Gadd45gip1^tm2Kong/Gadd45gip1^tm2Kong Tg(Vil1-cre)997Gum/0 (B and D) embryos. Paraffin sections were immunostained with anti-villin (A and B, in red) and anti-intestinal fatty acid-binding protein antibodies (C and D, in red). Original magnification was X200 (A-D). E and F, transmission electron photomicrographs of microvilli on the apical cell membranes. Note that the Gadd45gip1^tm2Kong/Gadd45gip1^tm2Kong Tg(Vil1-cre)997Gum/0 intestines have abnormal sizes and numbers of microvilli (F). Bars, 0.2 um.

Copyright

This image is from Kwon MC, J Biol Chem 2009 Nov 27;284(48):33634-41 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:156319

Associated Alleles

Symbol	Name
Gadd45gip1^tm2Kong	growth arrest and DNA-damage-inducible, gamma interacting protein 1; targeted mutation 2, Young-Yun Kong
Tg(Vil1-cre)997Gum	transgene insertion 997, Deborah L Gumucio

Associated Genotypes

Allelic Composition	Genetic Background
Gadd45gip1^tm2Kong/Gadd45gip1^tm2Kong Tg(Vil1-cre)997Gum/0	involves: 129P2/OlaHsd * C57BL/6J * SJL