Phenotype Image Detail

Image

Caption

Augmented activation of microglia and astrocytes in the brain of aged Grn^tm1.1Aidi/Grn^tm1.1Aidi (KO) mice. (A) Activation of microglia and astrocytes in mutant mice. Hippocampal, cortical, and thalamic sections from 18-month-old wild-type (WT) and mutant (KO) mice (n = 6) were immunostained using antibody against CD68 or GFAP. (B) Activated CD68+ and GFAP+ cells were expressed as cells per square millimeter within indicated regions of both cerebral hemispheres of each animal. Results are means SEM from three independent experiments. *, P<0.01 using the Student's t test. Bar, 80 um.

Copyright

This image is from Yin F, J Exp Med 2010 Jan 18;207(1):117-28, S1-4, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:156824

Associated Alleles

Symbol	Name
Grn^tm1.1Aidi	granulin; targeted mutation 1.1, Aihao Ding

Associated Genotypes

Allelic Composition	Genetic Background
Grn^tm1.1Aidi/Grn^tm1.1Aidi	involves: C57BL/6 * C57BL/6J
Grn^tm1.1Aidi/Grn^tm1.1Aidi	involves: C57BL/6J