Phenotype Image Detail

Image

Caption

Assessment of the cerebrospinal fluid (CSF) pathway by an intra-ventricular injection of India ink in p23-ST1/p23-ST1 mice. Mice (12 months old, n=3 in each group) were intraventricularly injected with India ink. Whole-brain (upper left panel and lower panel) and serial brain sections (upper right panel) were analyzed 10 min post injection for ink distribution and diffusion in the brain of control (A) and mutant mice (B). Tissue sections from a control mouse injected with saline are shown as a negative control (C). Diffuse ink was clearly observed in the lateral, third, and fourth ventricles of both control (A) and mutant mice (B). Likewise, the darkly ink-stained vessels at the cerebrum (green arrows), cerebellum, and spinal cord (black arrows) were also evident in both mutant and control mice. No dark-blue staining was found in the brain of the negative control (C). Yellow arrows mark the injection sites. Representative pictures of three independent mice in each group are shown.

Copyright

This image is from Lee MJ, PLoS One 2009;4(11):e7868, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:158278

Associated Alleles

Symbol	Name
p23-ST1	p23-ST1

Associated Genotypes

Allelic Composition	Genetic Background
p23-ST1/p23-ST1	C57BL/6J-p23-ST1