Phenotype Image Detail

Image

Caption

Gait analysis of p23-ST1/p23-ST1 mice. The gait status of aged mice (20-24 months old) was assessed by the CatWalk automatic gait analysis system. Real-time gait images of mutant and control mice are shown in panels A, C, and E. Footprint colors were assigned by the program (green, right; red, left; light, forelimbs; dark, hindlimbs). (A) Stumbling gait (i.e., gait apraxia, white arrows) of mutant mice (lower trace) but not control individuals (upper trace). Note that the forepaws were conspicuously affected. (B) Percentages of mis-placed feet in both mutant and control mice are presented graphically. The difference between the two groups was significant at p < 0.01. (C) The unsteady, wobbly gait of mutant mouse compared with a control animal that moved in a straight line. The distance between the left (white line) and right (yellow line) path along with the midline was determined. (D) Graphical presentation of these data. The shift from the midline was more significant in mutant than control mice (p<0.05). To evaluate the motor performance and gait balance, the distance of the stride lengths as well as the distance between the bilateral paws were measured (E and F). Mutant mice showed a reduction in stride length and a wider base between the hind paws (p<0.05) (F). Data are presented as the mean +/-SEM in each group.

Copyright

This image is from Lee MJ, PLoS One 2009;4(11):e7868, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:158278

Associated Alleles

Symbol	Name
p23-ST1	p23-ST1

Associated Genotypes

Allelic Composition	Genetic Background
p23-ST1/p23-ST1	C57BL/6J-p23-ST1