Phenotype Image Detail

Image

Caption

Alterations in the numbers of neurons, astrocytes, and microglia in the dorsal lateral septal nu (LSD) of p23-ST1/p23-ST1 mice. Brain sections containing the LSD from mutant and control mice (n=3-6) were stained with Nissl stain (A, E), or the corresponding antibody against a neuronal marker (NeuN, B), an astrocyte marker (GFAP, C), or a microglia marker (Iba1, D). The density (A) and morphology (B) of LSD neurons were altered in mutant mice (A, arrows). Activation of astrocytes with thicker processes was also evident in mutant animals (C, F). The number of chronically activated microglia, characterized by their elongated and bipolar morphology with Iba1-positive immunoreactivity, was markedly increased in mutant mice (D; arrowheads, G). Representative pictures of the LSD of aged mutant mice are presented (A, B, C, D). A specific comparison between mutant and control mice was conducted using Student's t-test (* p<0.05, ** p<0.01, *** p<0.001). Data are presented as the mean +/- SEM.

Copyright

This image is from Lee MJ, PLoS One 2009;4(11):e7868, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:158278

Associated Alleles

Symbol	Name
p23-ST1	p23-ST1

Associated Genotypes

Allelic Composition	Genetic Background
p23-ST1/p23-ST1	C57BL/6J-p23-ST1