Phenotype Image Detail

Image

Caption

Skeletal defects in Mstn^tm1Sjl/Mstn^tm1Sjl and Mstn^tm1Sjl/Mstn^tm1Sjl Gdf11^tm1Sjl/Gdf11^tm1Sjl newborn mice. (A) Thoracic region of Gdf11^tm1Sjl/Gdf11^tm1Sjl (Gdf11-/-) (A) and Mstn^tm1Sjl/Mstn^tm1Sjl Gdf11^tm1Sjl/Gdf11^tm1Sjl (Mstn-/- Gdf11-/-) (B) mutants showing the increase in rib number. Note that the anterior homeotic transformations of thoracic vertebrae are more extensive in the double mutant (20 ribs) versus the single Gdf11^tm1Sjl/Gdf11^tm1Sjl (Gdf11-/-) mutant (18 ribs). Whole skeleton preparation of the single mutant (C) and double mutant (D) pups. (E) Ventral torso of newborn double mutant showing multiple projections from the skin (*) and an extra limb (arrowhead). Forelimb skeleton preparations of single mutant (F) and double mutant (G and H) pups showing an extra bone emanating from the shoulder of the double mutant (G, arrow) and an extra limb (H). The limb in (G) has been rotated for a better view of the extra bone. (I and J) Hindlimb phenotypes of double mutant pups. Note the truncation of the vertebral column (I) and malformation of the ilieum and all leg bones (J).

Copyright

This image is from McPherron AC, BMC Dev Biol 2009;9():24, an open-access article, licensee BioMed Central Ltd. J:158173

Associated Alleles

Symbol	Name
Gdf11^tm1Sjl	growth differentiation factor 11; targeted mutation 1, Sejin Lee
Mstn^tm1Sjl	myostatin; targeted mutation 1, Se-Jin Lee

Associated Genotypes

Allelic Composition	Genetic Background
Gdf11^tm1Sjl/Gdf11^tm1Sjl	involves: 129S1/Sv * 129X1/SvJ
Gdf11^tm1Sjl/Gdf11^tm1Sjl Mstn^tm1Sjl/Mstn^tm1Sjl	involves: 129S1/Sv * 129X1/SvJ