Phenotype Image Detail

Image

Caption

Liver zonation is affected in hypomorphic Apc^tm1Tno/Apc^tm1Tno (fl/fl) mutant mice. (A) Immunohistochemical expression analysis for beta-catenin, glutamine synthetase (GS), carbamoylphosphate synthetase (CPS) and Cyp2E1 was performed on livers of age-matched wild-type (+/+) and Apc^tm1Tno/Apc^tm1Tno (fl/fl) mice. Arrows point to nuclear beta-catenin staining. Mutants show increased number of cells with nuclear beta-catenin and altered liver zonation.

Copyright

This image is from Buchert M, PLoS Genet 2010 Jan;6(1):e1000816, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:156864

Associated Alleles

Symbol	Name
Apc^tm1Tno	APC, WNT signaling pathway regulator; targeted mutation 1, Tetsuo Noda

Associated Genotypes

Allelic Composition	Genetic Background
Apc^tm1Tno/Apc^tm1Tno	involves: 129 * 129S4/SvJae * C57BL/6