Phenotype Image Detail

Image

Caption

Loss of Speedy A leads to depletion of male and female germ cells. B) Ovaries from PD35 wild-type (WT, Spdya+/+) and Spdya^tm1.1Klad/Spdya^tm1.1Klad female mice. (C) Testes from PD35 WT and Spdya^tm1.1Klad/Spdya^tm1.1Klad male mice. (D and E) At PD7, the number of spermatogonia was comparable between WT and mutant testes as indicated by DDX4 staining. (F and G) By PD18, the number of spermatogonia was comparable between WT (F) and mutant testes (G), but some seminiferous tubules showed depletion of spermatocytes in mutant testes (G, arrowhead). (H and I) By PD75, most of the mutant seminiferous tubes were depleted of spermatocytes (arrowhead). (J and K) At 17.5 dpc, the numbers of oocytes were comparable between WT (J) and mutant ovaries (K). (L and M) The number of oocytes was much lower in the mutant ovary (M) compared with the WT ovary at PD1 (L). (N and O) At PD5, the mutant ovaries were depleted of oocytes (O, arrow) compared with the WT ovary (N).

Copyright

This image is from Tu Z, Proc Natl Acad Sci U S A 2017 Jan 17;114(3):592-597. Copyright 2017 National Academy of Sciences, U.S.A. J:239544

Associated Alleles

Symbol	Name
Spdya^tm1.1Klad	speedy/RINGO cell cycle regulator family, member A; targeted mutation 1.1, Phillip Kladis

Associated Genotypes

Allelic Composition	Genetic Background
Spdya^tm1.1Klad/Spdya^tm1.1Klad	involves: 129S1/Sv * C57BL/6J