Phenotype Image Detail

Image

Caption

In wild-type (WT) mouse (B), there were many corpora lutea (black arrow) and follicles at different stages of growth. Healthy early antral follicles (gray arrow), healthy preovulatory follicles (dotted arrow), and atretic follicles (white arrow) are present. In the Esr2^tm1.1Gust/Esr2^tm1.1Gust (ER-Deltaex3) infertile mouse (C), there were many preantral follicles and a few early antral follicles (gray arrow). Most late antral follicles are atretic (white arrow). There was no corpus luteum. In conclusion, mutant mouse ovaries display more atretic follicles and less corpora lutea than WT mice. There was no significant difference in the number of developing follicles between the WT and the mutant mice.

Copyright

This image is from Maneix L, Proc Natl Acad Sci U S A 2015 Apr 21;112(16):5135-40. Copyright 2015 National Academy of Sciences, U.S.A. J:220968

Associated Alleles

Symbol	Name
Esr2^tm1.1Gust	estrogen receptor 2 (beta); targeted mutation 1.1, Jan-Ake Gustafsson

Associated Genotypes

Allelic Composition	Genetic Background
Esr2^tm1.1Gust/Esr2^tm1.1Gust	B6J.129X1(Cg)-Esr2^tm1.1Gust