Phenotype Image Detail

Image

Caption

Ultrastructural features of contractile and synthetic smooth muscle cells (SMCs) in Mirc32^tm1Thbr/Mirc32^tm1Thbr mice. (A) Typical contractile SMCs from wild-type animals show numerous focal adhesions (arrows) and intracellular dense bodies (arrowheads). (B) In contrast, synthetic SMCs from mutant mice only rarely display focal adhesions (arrow) and intracellular dense bodies and are rich in rough ER (rER).

Copyright

This image is from Boettger T, J Clin Invest 2009 Sep;119(9):2634-47 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152702

Associated Alleles

Symbol	Name
Mirc32^tm1Thbr	microRNA cluster 32, including Mir143 and Mir145a; targeted mutation 1, Thomas Braun

Associated Genotypes

Allelic Composition	Genetic Background
Mirc32^tm1Thbr/Mirc32^tm1Thbr	involves: 129/Sv * C57BL/6