Phenotype Image Detail

Image

Caption

Changes in the morphology of vessels walls of Mirc32^tm1Thbr/Mirc32^tm1Thbr (KO) mice at different ages. (A-B) Representative light microscopic images comparing the thickness of the media in wild-type (WT) and mutant vessel walls. Note the reduced cellular area of vascular smooth muscle cells and a decreased media thickness in mutant compared to WT mice. (C, D) Vessels of older mutant mice (18 month) did frequently contain neointimal lesions, which were never seen in WT mice.

Copyright

This image is from Boettger T, J Clin Invest 2009 Sep;119(9):2634-47 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152702

Associated Alleles

Symbol	Name
Mirc32^tm1Thbr	microRNA cluster 32, including Mir143 and Mir145a; targeted mutation 1, Thomas Braun

Associated Genotypes

Allelic Composition	Genetic Background
Mirc32^tm1Thbr/Mirc32^tm1Thbr	involves: 129/Sv * C57BL/6