Phenotype Image Detail

Image

Caption

Ptpn11^tm4.2Bgn/Ptpn11⁺ (LS/+) mice demonstrate phenotypic abnormalities similar to those in human Leopard syndrome. (A) Representative photographs of en face and nose bridge profile (arrow) (image was brightened to enable a clear view of the facial phenotype). (B) Skeletal/chest deformity in heterozygous mutant mice, with pectus carinatum superiorly (arrow) and pectus excavatum inferiorly (arrow). (C) Overall smaller body size in mutant mice as compared with that of wild-type (WT) mice.

Copyright

This image is from Marin TM, J Clin Invest 2011 Mar 1;121(3):1026-43 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172033

Associated Alleles

Symbol	Name
Ptpn11^tm4.2Bgn	protein tyrosine phosphatase, non-receptor type 11; targeted mutation 4.2, Benjamin G Neel

Associated Genotypes

Allelic Composition	Genetic Background
Ptpn11^tm4.2Bgn/Ptpn11^+	involves: 129S6/SvEvTac * C57BL/6J * FVB/N