Phenotype Image Detail

Image

Caption

(B) H&E-stained sections (original magnification x400; scale bar: 100 um) depicting myofiber disarray and enlarged nuclei in 52-week-old Ptpn11^tm4.2Bgn/Ptpn11⁺ (LS/+) hearts. (C) Masson-Trichrome stain of paraffin-embedded longitudinal heart sections from wild-type (WT) and mutant mice reveals marked fibrosis in mutant hearts at 52 weeks of age (original magnification, x400). Fibrous tissue is stained in blue and magnified in inset. (D) Reticulin stain of paraffin-embedded heart sections from 52-week-old WT and mutant mice (original magnification, x400), showing enlarged mutant cardiomyocytes.

Copyright

This image is from Marin TM, J Clin Invest 2011 Mar 1;121(3):1026-43 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172033

Associated Alleles

Symbol	Name
Ptpn11^tm4.2Bgn	protein tyrosine phosphatase, non-receptor type 11; targeted mutation 4.2, Benjamin G Neel

Associated Genotypes

Allelic Composition	Genetic Background
Ptpn11^tm4.2Bgn/Ptpn11^+	involves: 129S6/SvEvTac * C57BL/6J * FVB/N