Phenotype Image Detail

Image

Caption

Ptpn11^tm4.2Bgn/Ptpn11⁺ (LS/+) mice have hypertrophic cardiomyopathy that progresses to chamber dilation. Representative echocardiographs of wild-type (WT) and mutant mice at 12 to 14 weeks of age and 52 weeks of age, respectively. Two-headed arrows indicate left ventricle chamber size. Note that at 12 weeks, mutant hearts have small chamber dimensions compared with those of WT controls; at 52 weeks, mutant hearts have increased chamber dimensions and have dilated/decompensated compared with those of WT controls.

Copyright

This image is from Marin TM, J Clin Invest 2011 Mar 1;121(3):1026-43 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:172033

Associated Alleles

Symbol	Name
Ptpn11^tm4.2Bgn	protein tyrosine phosphatase, non-receptor type 11; targeted mutation 4.2, Benjamin G Neel

Associated Genotypes

Allelic Composition	Genetic Background
Ptpn11^tm4.2Bgn/Ptpn11^+	involves: 129S6/SvEvTac * C57BL/6J * FVB/N