Phenotype Image Detail

Image

Caption

Defective spermatogenesis and acrosome formation in Gorasp2^tm1.1Maal/Gorasp2^tm1.1Maal (Gorasp2-/-) mice. (A) Sections of epididymis from control littermate and mutant mice stained with hematoxylin and eosin. Note that most of the mutant lumens are empty and that some of them contain large round cells instead of differentiated spermatozoa (inserts). Scale bars: top panels, 100 um; bottom panels, 50 um; inserts, 10 um. (B) Sections of testes from 35 days-old control and mutant mice stained for the acrosomal protein SP56. Scale bar, 100 um. (C) High magnification images of knock-out and control testes sections stained with anti-SP56 and peanut agglutinin (PNA). Note that SP56 staining is more restricted than PNA staining. Scale bar, 10 um.

Copyright

This image is from Cartier-Michaud A, PLoS Genet 2017 Jun;13(6):e1006803, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:241919

Associated Alleles

Symbol	Name
Gorasp2^tm1.1Maal	golgi reassembly stacking protein 2; targeted mutation 1.1, Michel Aurrand-Lions

Associated Genotypes

Allelic Composition	Genetic Background
Gorasp2^tm1.1Maal/Gorasp2^tm1.1Maal	B6J.129S2(Cg)-Gorasp2^tm1.1Maal