Phenotype Image Detail

Image

Caption

Rods and cones in Rho^tm1.1Kpal/Rho⁺ (P23H/+) mice. Cryo-sections from postnatal day (PND) 35 wild-type (WT) and heterozygous (P23H/+) mice from the same litter were double-stained with opsin (1D4) antibody and peanut agglutinin (PNA) lectin. Images labeled with same marker were captured under identical conditions. Significant shortening of rod outer segment (ROS) was observed in P23H/+ mice, but the number of cone photoreceptor cells labeled by PNA was not reduced by this age. RPE, retinal pigmented epithelium; ONL, outer nuclear layer; INL, inner nuclear layer; IPL, inner plexiform layer; GC/NFL, ganglion cells/nerve fiber layer; DIC, differential interference contrast.

Copyright

This image is from Sakami S, J Biol Chem 2011 Mar 25;286(12):10551-67 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:170648

Associated Alleles

Symbol	Name
Rho^tm1.1Kpal	rhodopsin; targeted mutation 1.1, Krzysztof Palczewski

Associated Genotypes

Allelic Composition	Genetic Background
Rho^tm1.1Kpal/Rho^+	involves: 129S6/SvEvTac * C57BL/6 * FVB/N