Phenotype Image Detail

Image

Caption

(B) Plastic sections of retinas from postnatal day (PND) 63 wild-type (WT) and Rho^tm1.1Kpal/Rho⁺ (P23H/+) mice were stained with toluidine blue. Rod and cone photoreceptor nuclei were distinguishable by the shape of their chromatin; cone nuclei are indicated by arrows. We also identified dead rod photoreceptor nuclei that had lost clumps of chromatin (indicated by arrowheads). (C) Transmission electron microscopy (TEM) images reveal dead photoreceptor cell nuclei in both WT and heterozygous mice. IS, inner segment; OLM, outer limiting membrane; and ONL, outer nuclear layer.

Copyright

This image is from Sakami S, J Biol Chem 2011 Mar 25;286(12):10551-67 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:170648

Associated Alleles

Symbol	Name
Rho^tm1.1Kpal	rhodopsin; targeted mutation 1.1, Krzysztof Palczewski

Associated Genotypes

Allelic Composition	Genetic Background
Rho^tm1.1Kpal/Rho^+	involves: 129S6/SvEvTac * C57BL/6 * FVB/N