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Caption | Abnormal Z line organization in E14.5 Casz1Gt(CJ0565)Wtsi/Casz1Gt(CJ0565)Wtsi (Casz1betageo/betageo) heart. A, cardiomyocytes isolated from wild-type (WT, Casz1+/+) and mutant E14.5 embryo hearts were cultured in vitro for 2 days and immunostained for alpha-actinin (red) and F-actin (green), whereas the nuclei were stained with DAPI (blue). Representative images show that clear Z lines were presented in the WT cardiomyocytes, but not in the mutant cardiomyocytes. C, more representative images show that clear Z lines are present in the WT cardiomyocytes. There are no clear Z lines in these mutant cardiomyocytes, and the alpha-actinin staining pattern is distinct compared with the WT cardiomyocytes. | ||||
Copyright | This image is from Liu Z, J Biol Chem 2014 Oct 24;289(43):29801-16 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:242127 | ||||
Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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