Phenotype Image Detail

Image

Caption

Increased susceptibility to induced colitis in Nlrp6^tm1Macha/Nlrp6^tm1Macha mice. Wild-type (Nlrp6+/+) and Nlrp6^tm1Macha/Nlrp6^tm1Macha (Nlrp6-/-) mice were challenged with 3% dextran sodium sulfate (DSS) for 6 or 7 days followed by a 10 day period of regular drinking water. (C). Endoscopic analysis was made before necropsy to observe the tissue damage after 6 days of DSS treatment. Representative photographs of dissected wild-type and Nlrp6^tm1Macha/Nlrp6^tm1Macha mice at day 6 (D) and day 17 (H). The histological score was evaluated on serial colonic sections stained with H&E at day 6 (from nine wild-type and six mutant mice) (F).

Copyright

This image is from Normand S, Proc Natl Acad Sci U S A 2011 Jun 7;108(23):9601-6. Copyright 2011 National Academy of Sciences, U.S.A. J:173352

Associated Alleles

Symbol	Name
Nlrp6^tm1Macha	NLR family, pyrin domain containing 6; targeted mutation 1, Mathias Chamaillard

Associated Genotypes

Allelic Composition	Genetic Background
Nlrp6^tm1Macha/Nlrp6^tm1Macha	involves: 129S5/SvEvBrd * C57BL/6J