Phenotype Image Detail

Image

Caption

Nlrp6^tm1Macha/Nlrp6^tm1Macha (Nlrp6-/-) mice develop more tumors than control after experimental chronic inflammation in an experimental model of colorectal tumorigenesis. Five days after AOM administration (at 8 mg/kg), wild-type (Nlrp6+/+; n = 8) and mutant (n = 8) mice were subjected to four rounds of 2% DSS for 5 days interspersed with 7-day access to regular drinking water. C) Endoscopic analysis of wild-type and Nlrp6^tm1Macha/Nlrp6^tm1Macha mice at day 49. Representative photographs of dissected colon (D) and of H&E staining of paraformaldehyde-fixed tissue (E) at necropsy.

Copyright

This image is from Normand S, Proc Natl Acad Sci U S A 2011 Jun 7;108(23):9601-6. Copyright 2011 National Academy of Sciences, U.S.A. J:173352

Associated Alleles

Symbol	Name
Nlrp6^tm1Macha	NLR family, pyrin domain containing 6; targeted mutation 1, Mathias Chamaillard

Associated Genotypes

Allelic Composition	Genetic Background
Nlrp6^tm1Macha/Nlrp6^tm1Macha	involves: 129S5/SvEvBrd * C57BL/6J