Phenotype Image Detail

Image

Caption

Appearance of wild-type (FAK^+/+) and Ptk2^tm1Heen/Ptk2^tm1Heen (FAK^delta/delta) embryos at E13.5 and E15.5 (arrows, hemorrhages; arrowheads, edemas). Gross morphology defects of E14.5 wild-type and mutant lungs, heart, and liver (scale bars, 1 mm). E14.5 (upper panel) and E15.5 (lower panel) anterior (left) and posterior (right) footplates (scale bars, 1 mm). D, Mutant embryos show delayed artery formation and vascular remodeling defects. Whole-mount triple immunofluorescence confocal microscopy using antibodies to smooth muscle actin (SMA, green), PECAM1 (red), and neurons (TUJ1) (blue) on skin from E14.5 embryos. Confocal microscopy images were acquired using X10 magnification.

Copyright

This image is from Corsi JM, J Biol Chem 2009 Dec 11;284(50):34769-76 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:157804

Associated Alleles

Symbol	Name
Ptk2^tm1Heen	PTK2 protein tyrosine kinase 2; targeted mutation 1, Herve Enslen

Associated Genotypes

Allelic Composition	Genetic Background
Ptk2^tm1Heen/Ptk2^tm1Heen	involves: 129/Sv * C57BL/6