Phenotype Image Detail

Image

Caption

Apoptotic defects in Slc20a1^tm1.2Lbek/Slc20a1^tm1.2Lbek (delta5/delta5) fetal liver cells. (A-B) Cytokeratin 18 (CK18) staining (brown) reveals the presence of hepatoblasts in E12.5 mutant sections (black arrows). (C-D) Staining of Ter119 (brown) reveals great loss of erythroid cells in E12.5 mutant liver sections (black arrows). (E-F) Activated caspase 3 staining of E12.5 liver sections reveals excessive apoptotic activity in mutant liver sections (black arrow) that was not present in Ter119 positive cells (white arrows). Bar, 100 um.

Copyright

This image is from Beck L, PLoS One 2010;5(2):e9148, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:157997

Associated Alleles

Symbol	Name
Slc20a1^tm1.2Lbek	solute carrier family 20, member 1; targeted mutation 1.2, Laurent Beck

Associated Genotypes

Allelic Composition	Genetic Background
Slc20a1^tm1.2Lbek/Slc20a1^tm1.2Lbek	involves: 129S2/SvPas * BALB/c * C57BL/6 * C57BL/6J