Phenotype Image Detail

Image

Caption

Reduced expression of Lhx2 hampers hair follicle morphogenesis. (A,B) Alkaline phosphatase (AP) staining of skin sections of E16.5 embryos (A) and E18.5 embryos (B) revealing the number of hair follicles (HFs) in skin of control embryos (upper panels) compared to skin in Lhx2^tm1Lcar/Lhx2^tm1Lcar (Lhx2^Neo/Neo) embryos (lower panels). (C) Estimation of HF density based on the AP staining of skin of E16.5 embryos (left) and E18.5 embryos (right) comparing control embryos to mutant embryos. Data are presented as average +/- SD. *p < 0.005. **p < 0.0001 (Student's t-test). (D) Skin sections of E16.5 embryos were analysed by in situ hybridization for expression of the indicated genes encoding mediators of signaling pathways involved in HF morphogenesis (arrow heads), and analysed by immunohistochemistry for expression of E-cad in epidermis comparing control embryos (upper panels) to mutant embryos (lower panels). Scale bars, 100 um.

Copyright

This image is from Tornqvist G, PLoS Genet 2010;6(4):e1000904, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:159209

Associated Alleles

Symbol	Name
Lhx2^tm1Lcar	LIM homeobox protein 2; targeted mutation 1, Leif Carlsson

Associated Genotypes

Allelic Composition	Genetic Background
Lhx2^tm1Lcar/Lhx2^tm1Lcar	involves: 129/Sv * C57BL/6