Phenotype Image Detail

Image

Caption

Absence of the common peroneal nerve and disappearance of the craniolateral hindlimb muscle fibers in Rnd3^{Gt(OST364657)Lex}/Rnd3^{Gt(OST364657)Lex} (gt/gt) mice. A) Top panels: Dissection of the hindlimb of representative postnatal day (PD) 21 wild-type (WT, +/+), heterozygous (+/gt) and homozygous (gt/gt) mutant mice. The common peroneal nerve was absent in all the homozygous mutant mice (right panel). Arrows indicate the presence of the common peroneal nerve in the WT (left panel) and in the heterozygous (central panel) and its absence in the homozygous mutant sample (right panel). Bottom panels: The two main components (tibial and common peroneal) of a sciatic nerve removed from a WT mouse (left panel) and from a heterozygous (central panel) can be observed, whereas the sciatic nerve of a mutant mouse only shows the tibial nerve. B) The spinal roots originating the sciatic nerve in a WT (top) and in a homozygous mutant (bottom) mouse are similar. The figure on the right shows a schematic representation of the roots. C) Histological section of a left P15 hindlimb from a WT (left panels) and a homozygous mutant (right panels) mouse. The lower panels show a higher magnification of the area in the upper rectangle. The dotted lines represent the area covered by the craniolateral muscles in the WT and in the homozygous mutant mice. Note that in the homozygous mutant hindlimb almost all muscle cells have been replaced by adipose tissue and clusters of small size fibers. TA: tibialis anterior muscle, EDL: extensor digitorum longus muscle, T: tibia, F: fibula.

Copyright

This image is from Mocholi E, PLoS One 2011;6(4):e19236, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172361

Associated Alleles

Symbol	Name
Rnd3^Gt(OST364657)Lex	Rho family GTPase 3; gene trap OST364657, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Rnd3^Gt(OST364657)Lex/Rnd3^Gt(OST364657)Lex	involves: 129S5/SvEvBrd * C57BL/6J