Phenotype Image Detail

Image

Caption

Tg(Th-MYCN)41Waw/0 mouse tumor imaging by MRI and ultrasound. The left column shows tumor progression at four distinct time points (top: first, button: last) as depicted by T2 weighted MRI. The tumor was manually segmented (red outline) on multi-slice coronal images and the volume averaged over all slices at each time point. The purple line traces the course of the aorta. Neuroblastomas are typically hypointense on T1- weighted images (VIBE data not shown) and hyperintense on T2-weighted images and can be seen on these images, especially in the later stages. The tumors appear to arise ventral to the aorta and demonstrate heterogeneous patterns, possibly from calcifications and hemorrhagic areas. Ultrasound data, also showing anatomical location of tumor (red) relative to aorta (purple), are presented as single slices (horizontal plane) and isosurface models generated from 3D data sets. Both imaging methods confirmed rapid growth of these representative tumors (and tight correlation across modalities) over the 30 day study period as described graphically to the right.

Copyright

This image is from Teitz T, PLoS One 2011;6(4):e19133, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172448

Associated Alleles

Symbol	Name
Tg(Th-MYCN)41Waw	transgene insertion 41, William A Weiss

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Th-MYCN)41Waw/0	involves: 129X1/SvJ * BALB/c * C57BL/6J