Phenotype Image Detail

Image

Caption

Histopathology of the brain stem and cerebellum in Aspa^{tm1a(EUCOMM)Wtsi}/Aspa^{tm1a(EUCOMM)Wtsi} mice. Caudal brain stem of controls (A, C, F, G) and mutant mice (B, D, E, H): Vacuolization is abundant in the dorsal region mutant mice (solitary tract nu, commissural, SolC) as shown in semithin sections (B) and electron microscopy (H). In the pyramidal tract of mutant mice myelin appears normal, but axonal swellings and degeneration are present (D, asterisks). Axonal swellings as well as hypo-myelination were found in the dorsal region with abundant vacuolization (F, asterisk). Cerebellum of controls (I, K, M, O) and mutant mice (J, L, N, P): In semithin sections of mutant cerebellum, vacuoles are detectable in the white matter (WM), granule cell layer (GL) and in the Purkinje cell layer (J, L). Parallel fibre to Purkinje cell dendrite synapses appear normal (M, N), but in mutant mice the Bergman glia (BG) is swollen and shows accumulation of electron dense particles (N, P). BG, Bergman glia; CC, central canal; GL, granule cell layer; ML, molecular layer; PC, Purkinje cell; PF, parallel fibre; SolC, solitary tract nu, commissural; WM, white matter. Scale bars: 100 um (A, B, I, J), 5 um (K, L), 2 um (G, H), 1 um (C, D, O, P), 500 nm (M, N).

Copyright

This image is from Mersmann N, PLoS One 2011;6(5):e20336, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172582

Associated Alleles

Symbol	Name
Aspa^tm1a(EUCOMM)Wtsi	aspartoacylase; targeted mutation 1a, Wellcome Trust Sanger Institute
Aspa^tm1a(EUCOMM)Wtsi	aspartoacylase; targeted mutation 1a, Wellcome Trust Sanger Institute

Associated Genotypes

Allelic Composition	Genetic Background
Aspa^tm1a(EUCOMM)Wtsi/Aspa^tm1a(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N