Phenotype Image Detail

Image

Caption

Histological analyses reveal premature wear out of the articulating disc in the temporomandibular joint (TMJ) of Shox2^{tm2.1(SHOX_a)Ypc}/Shox2^{tm2.1(SHOX_a)Ypc} (Shox2^KI/KI) mice. Coronal sections through the TMJ of wild-type (A, C, E, and G) and mutant mice (B, D, F, and H) at different ages. Note that the articulating disc in the knock-in mice appears comparable with that in the control at P0 (A and B), but becomes almost complete wear out at P21 (H and inset). C, condyle; d, disc; 7gf, glenoid fossa; lsc, lower synovial cavity; usc, upper synovial cavity. Scale bar, 500 um.

Copyright

This image is from Liu H, J Biol Chem 2011 May 13;286(19):17029-38 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:172674

Associated Alleles

Symbol	Name
Shox2^tm2.1(SHOX_a)Ypc	SHOX homeobox 2; targeted mutation 2.1, YiPing Chen

Associated Genotypes

Allelic Composition	Genetic Background
Shox2^tm2.1(SHOX_a)Ypc/Shox2^tm2.1(SHOX_a)Ypc	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6