Phenotype Image Detail

Image

Caption

Disruption of meiosis in Syce3^tm1Rben/Syce3^tm1Rben mice. Histological analysis of testes (day 30) and ovaries (day 32) from wild-type (Syce3^+/+), heterozygous (Syce3^+/-), and Syce3^tm1Rben/Syce3^tm1Rben (Syce3^-/-) mice stained with haematoxylin and eosin. Mutant homozygous testis lack postmeiotic stages whereas all stages of the spermatogenic cycle occur in the wild-type testis. The size of homozgyous mutant ovaries is greatly reduced compared to wild-type littermates and additionally mutant ovaries are completely depleted of follicles. (Ser) Sertoli cells, (Sc) spermatocytes, (Sp) spermatids, (eSp) elongated spermatids, (aSc) apoptotic spermatocytes, (Sg) spermatogonia, (Oc) oocyte, (Od) oviduct. Long and short bars, 100 um and 175 um, respectively.

Copyright

This image is from Schramm S, PLoS Genet 2011 May;7(5):e1002088, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172714

Associated Alleles

Symbol	Name
Syce3^tm1Rben	synaptonemal complex central element protein 3; targeted mutation 1, Ricardo Benavente

Associated Genotypes

Allelic Composition	Genetic Background
Syce3^tm1Rben/Syce3^tm1Rben	involves: 129S1/Sv * 129X1/SvJ * C57BL/6