Phenotype Image Detail

Image

Caption

Loss of SYCE3 results in massive apoptotic events during spermatogenesis. (A) TUNEL assay on paraffin embedded testis sections from wild-type, heterozygous and homozygous Syce3^tm1Rben/Syce3^tm1Rben mice (day 30). TUNEL positive stained cells are labeled in green, DNA is shown in blue. Bar, 40 um. (B) Light microscopic images of testis sections from paraffin embedded mutant mice showing stage X-II, IV and V-VI tubules. In stage X-II type A spermatogonia and zygotene or pachytene spermatocytes are present. Stage IV is characterized by intermediate spermatogonia and apoptotic pachytene spermatocytes. In type V-VI, B type spermatogonia can be distinguished. (Ser) Sertoli cells, (P) pachytene cells, (A) type A spermatogonia, (aP) apoptotic pachytene cells, (In) intermediate spermatogonia and (B) type B spermatogonia. Bar, 10 um.

Copyright

This image is from Schramm S, PLoS Genet 2011 May;7(5):e1002088, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172714

Associated Alleles

Symbol	Name
Syce3^tm1Rben	synaptonemal complex central element protein 3; targeted mutation 1, Ricardo Benavente

Associated Genotypes

Allelic Composition	Genetic Background
Syce3^tm1Rben/Syce3^tm1Rben	involves: 129S1/Sv * 129X1/SvJ * C57BL/6