Phenotype Image Detail

Image

Caption

Col4a1^deltaex40/Col4a1⁺ mice have focal and variable cortical malformations. Representative cresyl violet stained coronal brain sections from adult wild-type (Col4a1+/+, WT) (A) and mutant (B-H) revealed cortical malformations characteristic of cobblestone lissencephaly in all mutant brains examined (n=6). In contrast to the well-defined cortical lamination observed in WT brains, mutant brains had variable abnormalities including disorganized cortical lamination (bracket in B), ectopias (C, enlarged in D), heterotopic regions (E and F), enlarged ventricles (G) and, occasionally, severe cortical malformations (H). Scale bars: A-C and E-H, 800 um; d, 200 um.

Copyright

This image is from Labelle-Dumais C, PLoS Genet 2011 May;7(5):e1002062, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172720

Associated Alleles

Symbol	Name
Col4a1^deltaex40	collagen, type IV, alpha 1; delta exon 40

Associated Genotypes

Allelic Composition	Genetic Background
Col4a1^deltaex40/Col4a1^+	involves: 129S/SvEv * C57BL/6J