Phenotype Image Detail

Image

Caption

Focal and variable cortical neuronal localization defects are developmental. Embryos pulsed-labeled with BrdU at E14 were harvested at birth and BrdU was immunolabeled in position matched coronal brain sections of wild-type (Col4a1+/+, WT) (A and F) and Col4a1^deltaex40/Col4a1⁺ (mutant) mice (B-E and G-J). In contrast to WT controls, in which BrdU labeled cells are distributed in a uniform layer in the outer cortex, all mutant brains had focal neuronal localization defects that ranged in severity from diffuse cell layers to ectopias and severely disorganized cortical lamination (note gradient of severity from B through E and from G through J). Similar results were observed in embryos labeled at E16. Scale bar, 500 um.

Copyright

This image is from Labelle-Dumais C, PLoS Genet 2011 May;7(5):e1002062, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172720

Associated Alleles

Symbol	Name
Col4a1^deltaex40	collagen, type IV, alpha 1; delta exon 40

Associated Genotypes

Allelic Composition	Genetic Background
Col4a1^deltaex40/Col4a1^+	involves: 129S/SvEv * C57BL/6J