Phenotype Image Detail

Image

Caption

Col4a1^deltaex40/Col4a1⁺ mice have focal breaches of the pial basement membrane during development. Representative images of laminin labeled (green) coronal brain sections from P0 wild-type (A-D) and Col4a1^deltaex40/Col4a1⁺ (E-L) revealed breaches of the pial basement membrane in mutant animals. All sections of WT brains examined (A-D) showed intact pial membranes (higher magnifications in D). In contrast, position-matched mutant brains display multiple focal disruptions of the pial basement membrane (arrows and asterisks in G and K) that are shown in higher magnification in H, and L. Notably, the high magnification image in L shows ectopic cells (DAPI in blue) that have breached the pial membrane adjacent to a disruption. Scale bars: A-C, E-G, and I-K, 500 um; D, H and L, 50 um.

Copyright

This image is from Labelle-Dumais C, PLoS Genet 2011 May;7(5):e1002062, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172720

Associated Alleles

Symbol	Name
Col4a1^deltaex40	collagen, type IV, alpha 1; delta exon 40

Associated Genotypes

Allelic Composition	Genetic Background
Col4a1^deltaex40/Col4a1^+	involves: 129S/SvEv * C57BL/6J