Phenotype Image Detail

Image

Caption

Col4a1^deltaex40/Col4a1⁺ mice have hippocampal neuronal localization defects. Representative cresyl violet stained coronal sections from adult wild-type (WT) (A-D) and position-matched mutant (E-H) brains revealed subtle but consistent neuronal localization defects in hippocampi of mutant mice. Regions of the CA1 (red boxes in A and E), CA3 (black boxes in A and E) and dentate gyrus (white boxes in A and E) are enlarged in B and F, C and G, and D and H, respectively. All mutant mice (n=6) had hippocampal defects that included focal distortions (red box in E, compared to A) as well as diffusion of pyramidal cell layers in the CA1 (F, compared to B) and CA3 (G, compared to C) regions and granular cell layers in the dentate gyrus (H, compared to D). Scale bars: A and E, 500 um; B-D and F-H, 100 um.

Copyright

This image is from Labelle-Dumais C, PLoS Genet 2011 May;7(5):e1002062, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172720

Associated Alleles

Symbol	Name
Col4a1^deltaex40	collagen, type IV, alpha 1; delta exon 40

Associated Genotypes

Allelic Composition	Genetic Background
Col4a1^deltaex40/Col4a1^+	involves: 129S/SvEv * C57BL/6J