Phenotype Image Detail

Image

Caption

Presence of reactive astrocytes in the brain of Col4a1^deltaex40/Col4a1⁺ mice. Representative coronal brain sections from adult wild-type (Col4a1+/+, WT) (A-C) and position matched mutant (D-F) mice labeled with anti-GFAP antibody revealed the presence of reactive astrocytes. Compared to WT brains (A), mutant mice had increased GFAP labeling in the cortex (D). Higher magnification images revealed increased labeling in mutant mice (E compared to B) and the astrocytic morphology of the labeled cells. Increased labeling was also detected in mutant hippocampi compared to WT (F compared to C). Scale bars: A, C, D, F 500 um; B and E, 100 um.

Copyright

This image is from Labelle-Dumais C, PLoS Genet 2011 May;7(5):e1002062, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:172720

Associated Alleles

Symbol	Name
Col4a1^deltaex40	collagen, type IV, alpha 1; delta exon 40

Associated Genotypes

Allelic Composition	Genetic Background
Col4a1^deltaex40/Col4a1^+	involves: 129S/SvEv * C57BL/6J