Phenotype Image Detail

Image

Caption

Olfactory sensory neurons axon targeting is perturbed in Ttc8^tm1Reed/Ttc8^tm1Reed (BBS8-/-) mice. The olfactory receptor reporter line M72TL, Or8a1b^tm4Mom, was crossed into a Ttc8^tm1Reed/Ttc8^tm1Reed background and axon targeting was analyzed by whole-mount X-Gal staining of PD15 mice. In dorsal views, axons project from the olfactory epithelium (OE) (on the bottom) to their targets in the olfactory bulb (OB). In wild-type (WT) mice, M72-tau:lacZ-expressing axons converge to one dorsal glomerulus in each bulb. In the OB of Ttc8^tm1Reed/Ttc8^tm1Reed mice, multiple glomeruli are innervated and individual fibers wander on the surface of the bulb.

Copyright

This image is from Tadenev AL, Proc Natl Acad Sci U S A 2011 Jun 21;108(25):10320-5. Copyright 2011 National Academy of Sciences, U.S.A. J:173465

Associated Alleles

Symbol	Name
Or8a1b^tm4Mom	olfactory receptor family 8 subfamily A member 1B; targeted mutation 4, Peter Mombaerts
Ttc8^tm1Reed	tetratricopeptide repeat domain 8; targeted mutation 1, Randall R Reed

Associated Genotypes

Allelic Composition	Genetic Background
Ttc8^tm1Reed/Ttc8^tm1Reed	involves: 129
Or8a1b^tm4Mom/Or8a1b^+ Ttc8^tm1Reed/Ttc8^tm1Reed	involves: 129 * 129P2/OlaHsd * C57BL/6