Phenotype Image Detail

Image

Caption

Tdrd7 regulates ribonucleoprotein remodeling of chromatoid bodies. (A-F) Electron microscopy of control heterozygous (Tdrd7^+/-; A, C, and E) and homozygous Tdrd7^tm1.1Chum/Tdrd7^tm1.1Chum (Tdrd7^-/-; B, D, and F) spermatocytes (A and B) and spermatids (C-F). (E and F) Higher magnification views of C and D. Arrows, inter-mitochondrial cement; arrowheads, chromatoid bodies; open arrow-head, processing body. (G and H) Double immunostain of control heterozgyous (G) and homozygous mutant (H) spermatids for chromatoid bodies (MVH) and processing bodies (TDRD9). (I-L) Immunoelectron microscopy of control heterozgyous (I and K) and homozygous mutant spermatids (J and L) with anti-MVH (I and J) and anti-MIWI (K and L) antibodies. The arrowheads indicate chromatoid bodies and the open arrowheads mark processing bodies. (Scale bars: A, B, E, F, and I-L, 500 nm; C and D, 2 um; G and H, 10 um.)

Copyright

This image is from Tanaka T, Proc Natl Acad Sci U S A 2011 Jun 28;108(26):10579-84. Copyright 2011 National Academy of Sciences, U.S.A. J:173550

Associated Alleles

Symbol	Name
Tdrd7^tm1.1Chum	tudor domain containing 7; targeted mutation 1.1, Shinichiro Chuma

Associated Genotypes

Allelic Composition	Genetic Background
Tdrd7^tm1.1Chum/Tdrd7^tm1.1Chum	involves: 129S6/SvEvTac * C57BL/6