Phenotype Image Detail

Image

Caption

Slc3a2^tm1.1Merl/Slc3a2⁺ Tg(Vil1-cre)997Gum/0 mice show reduced colonic tumorigenesis in a model of colitis-associated cancer (CAC). CAC induction protocol. Mice were intraperitoneally injected with AOM and maintained for 7 days, then subjected to 2 cycles of DSS treatment. (B) Representative control (CD98^fl/+) and Slc3a2^tm1.1Merl/Slc3a2⁺ Tg(Vil1-cre)997Gum/0 (CD98^fl/+ VilCre) colons at the end of the CAC protocol, with the number of tumors per mouse. (D) Representative H&E-stained colonic tumors at the end of the CAC protocol. Scale bars: 100 um. Data are from 1 experiment repeated twice with similar results. *P < 0.05, **P < 0.005, ***P < 0.001 vs DSS-treated controls.

Copyright

This image is from Nguyen HT, J Clin Invest 2011 May 2;121(5):1733-47 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:173946

Associated Alleles

Symbol	Name
Slc3a2^tm1.1Merl	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2; targeted mutation 1.1, Didier Merlin
Tg(Vil1-cre)997Gum	transgene insertion 997, Deborah L Gumucio

Associated Genotypes

Allelic Composition	Genetic Background
Slc3a2^tm1.1Merl/Slc3a2^+ Tg(Vil1-cre)997Gum/0	B6.Cg-Slc3a2^tm1.1Merl Tg(Vil1-cre)997Gum