Phenotype Image Detail

Image

Caption

Cardiac fibrosis in Med1^tm2Jkr/Med1^tm2Jkr A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ (TmcsMed1^-/-) mouse heart. TmcsMed1^-/- mice given daily injections of tamoxifen for 5 days were killed 14 days after the first tamoxifen injection. (A&B) Masson's trichrome staining was used to assess myocardial fibrosis. Inset in panel B shows intensely stained (blue color) interstitial fibrous strands.

Copyright

This image is from Jia Y, PLoS One 2016;11(8):e0160755, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:243730

Associated Alleles

Symbol	Name
A1cf^Tg(Myh6-cre/Esr1*)1Jmk	APOBEC1 complementation factor; transgene insertion 1, Jeffery D Molkentin
Med1^tm2Jkr	mediator complex subunit 1; targeted mutation 2, Janardan K Reddy
Tg(Myh6-cre)2182Mds	transgene insertion 2182, Michael D Schneider

Associated Genotypes

Allelic Composition	Genetic Background
Med1^tm2Jkr/Med1^tm2Jkr A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+	involves: 129P2/OlaHsd * FVB/N