Phenotype Image Detail

Image

Caption

Ultrastructure of degenerated hair cells of Marveld2^tm1Sats/Marveld2^tm1Sats (Tric^-/-) mice. (a-d) Scanning electron microscopy (SEM) images of the organ of Corti of wild-type (Tric^+/+) (a) and mutant (b-d) mice. (a) Inner hair cells (IHCs) (arrow) and outer hair cells (OHCs) (arrowheads) with normally organised arrays of stereocilia are observed in wild-type mice on P21. (b) Morphology of HCs is normal in mutant cochlea on P10. Note the V-shaped array of stereocilia in OHCs (inset). (c) Degeneration occurs frequently in OHCs but not in IHCs of mutant cochlea on P14. (d) Most HCs are lost except for some IHCs with severely deformed stereocilia (arrows) in mutant cochlea on P21. Scale bars = 6 um (a-d) and 1 um (inset in a).

Copyright

This image is from Kamitani T, Sci Rep 2015 Dec 18;5():18402, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:261357

Associated Alleles

Symbol	Name
Marveld2^tm1Sats	MARVEL (membrane-associating) domain containing 2; targeted mutation 1, Sachiko Tsukita

Associated Genotypes

Allelic Composition	Genetic Background
Marveld2^tm1Sats/Marveld2^tm1Sats	B6.Cg-Marveld2^tm1Sats