Phenotype Image Detail

Image

Caption

Analysis of livers in mice with heterozygous and homozygous Fbxw7^tm1.1Iken mutations. (A-C) Representative H&E staining of the livers of control (+/+) (A), Alb-Cre;Fbxw7LSL-R468C/+ (Fbxw7Hep-R468C/+;Hep-R468C/+) (B), and Alb-Cre;Fbxw7LSL-R468C/LSL-R468C (Fbxw7Hep-R468C/Hep-R468C;Hep-R468C/Hep-R468C) (C) mice at 12 months of age. Bar, 100 um. (D) Expression of Fbxw7 substrates in the livers of mice with the indicated genotype

Copyright

This image is from Ikenoue T, Sci Rep 2018 Jan 31;8(1):2021, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:258194

Associated Alleles

Symbol	Name
Fbxw7^tm1Iken	F-box and WD-40 domain protein 7; targeted mutation 1, Tsuneo Ikenoue
Speer6-ps1^Tg(Alb-cre)21Mgn	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson